| CAMPEONATO NACIONAL 2021 | ||||
| Campeonato de Apertura | ||||
| 1º Fecha | ||||
| 15-may-2021 | Montevideo | Villa Española | 0 | |
| Progreso | 0 | |||
| 15-may-2021 | Montevideo | Wanderers | 1 | Rivero |
| Boston River | 0 | |||
| 15-may-2021 | Montevideo | Torque | 0 | |
| Sud America | 1 | Olivera | ||
| 16-may-2021 | Montevideo | Rentistas | 0 | |
| Fenix | 3 | Nequecaur (2, 1P), Kaique | ||
| 16-may-2021 | Maldonado | Maldonado | 2 | Batista, Ramos |
| Liverpool | 4 | Ramirez (3, 1P), Martinez | ||
| 16-may-2021 | Montevideo | Cerrito | 3 | Silvera, Ferreira, Perez |
| River Plate | 1 | Bonifazi | ||
| 2-jun-2021 | Montevideo | Nacional | 1 | May |
| Cerro Largo | 2 | Otormin, Beltran | ||
| 2-jun-2021 | Montevideo | Peñarol | 0 | |
| Plaza Colonia | 0 | |||
| 2º Fecha | ||||
| 22-may-2021 | Las Piedras | Boston River | 1 | Bentancourt |
| Rentistas | 2 | Sosa, Villar | ||
| 22-may-2021 | Montevideo | Fenix | 0 | |
| Peñarol | 0 | |||
| 22-may-2021 | Melo | Cerro Largo | 3 | Otormin (3), Cayetano |
| Cerrito | 1 | Cruz | ||
| 23-may-2021 | Colonia | Plaza Colonia | 1 | Diogo |
| del Sacramento | Torque | 0 | ||
| 23-may-2021 | Montevideo | Progreso | 1 | F. Fernandez |
| Nacional | 3 | Bergessio, L. Fernandez, Trezza | ||
| 23-may-2021 | Montevideo | Wanderers | 0 | |
| Maldonado | 0 | |||
| 24-may-2021 | Montevideo | River Plate | 3 | Boggio, Rodriguez, Borbas |
| Liverpool | 2 | Ramirez (2P) | ||
| 24-may-2021 | Minas | Sud America | 2 | Olivera, Andrade |
| Villa Española | 1 | Digiano | ||
| 3º Fecha | ||||
| 29-may-2021 | Montevideo | Liverpool | 3 | Garcia, Martinez, Medina |
| Cerro Largo | 0 | |||
| 29-may-2021 | Montevideo | Villa Española | 1 | Olivera |
| Plaza Colonia | 3 | Fernandez, Diogo (2) | ||
| 29-may-2021 | Montevideo | Cerrito | 0 | |
| Progreso | 0 | |||
| 30-may-2021 | Maldonado | Maldonado | 0 | |
| River Plate | 0 | |||
| 30-may-2021 | Montevideo | Peñarol | 5 | Alvarez (2), Torres, Ceppelini (P), Trindade |
| Boston River | 2 | Nadruz, Bentancourt | ||
| 30-may-2021 | Montevideo | Nacional | 1 | Bergessio |
| Sud America | 0 | |||
| 31-may-2021 | Montevideo | Rentistas | 0 | |
| Wanderers | 1 | Lopez | ||
| 31-may-2021 | Montevideo | Torque | 2 | Catarozzi, Rodriguez |
| Fenix | 0 | |||
| 4º Fecha | ||||
| 4-jun-2021 | Montevideo | Progreso | 1 | Barboza |
| Liverpool | 3 | Martinez, Marta (A), Garcia | ||
| 5-jun-2021 | Colonia | Plaza Colonia | 1 | Dibble |
| del Sacramento | Nacional | 2 | Trezza, Bergessio (P) | |
| 5-jun-2021 | Minas | Sud America | 0 | |
| Cerrito | 0 | |||
| 6-jun-2021 | Las Piedras | Boston River | 1 | Alberti |
| Torque | 2 | Del Prete, Allende (P) | ||
| 6-jun-2021 | Montevideo | Rentistas | 0 | |
| Maldonado | 2 | Darias, Conechny | ||
| 6-jun-2021 | Melo | Cerro Largo | 2 | Otormin (P), Cayetano |
| River Plate | 4 | Borbas, Boggio, Arezo (2, 1P) | ||
| 6-jun-2021 | Montevideo | Wanderers | 0 | |
| Peñarol | 0 | |||
| 7-jun-2021 | Montevideo | Fenix | 1 | Franco |
| Villa Española | 0 | |||
| 5º Fecha | ||||
| 11-jun-2021 | Montevideo | Liverpool | 5 | Martinez (2), Ramirez (3) |
| Sud America | 0 | |||
| 11-jun-2021 | Montevideo | Torque | 2 | Del Prete (2) |
| Wanderers | 1 | Quagliata | ||
| 12-jun-2021 | Montevideo | River Plate | 4 | Salaberry, Borbas, Bonifazi, Castro |
| Progreso | 0 | |||
| 12-jun-2021 | Montevideo | Cerrito | 1 | Silvera |
| Plaza Colonia | 2 | Risso, Rodriguez | ||
| 12-jun-2021 | Montevideo | Peñarol | 1 | Canobbio |
| Rentistas | 1 | Perez | ||
| 13-jun-2021 | Maldonado | Maldonado | 2 | Vazquez (A), Batista (P) |
| Cerro Largo | 1 | Vazquez | ||
| 13-jun-2021 | Montevideo | Nacional | 3 | Bergessio (3) |
| Fenix | 1 | Mendez (A) | ||
| 14-jun-2021 | Montevideo | Villa Española | 2 | Silva, Olivera |
| Boston River | 2 | Betancourt (P), Larrosa | ||
| 6º Fecha | ||||
| 17-jun-2021 | Colonia | Plaza Colonia | 2 | Fernandez, Risso |
| del Sacramento | Liverpool | 1 | Fernandez | |
| 18-jun-2021 | Montevideo | Rentistas | 0 | |
| Torque | 2 | Rodriguez, Arismendi (P) | ||
| 18-jun-2021 | Montevideo | Fenix | 1 | Alvez |
| Cerrito | 3 | Silvera (3) | ||
| 19-jun-2021 | Montevideo | Sud America | 1 | Gimenez |
| River Plate | 2 | Arezo (2, 1P) | ||
| 19-jun-2021 | Montevideo | Progreso | 0 | |
| Cerro Largo | 0 | |||
| 19-jun-2021 | Las Piedras | Boston River | 1 | Rodriguez |
| Nacional | 1 | Bergessio | ||
| 19-jun-2021 | Montevideo | Wanderers | 3 | Quagliata, Abero, Lopez |
| Villa Española | 0 | |||
| 20-jun-2021 | Montevideo | Peñarol | 4 | Gargano, Alvarez (2), Varela (A) |
| Maldonado | 0 | |||
| 7º Fecha | ||||
| 22-jun-2021 | Montevideo | Liverpool | 5 | Ramirez (2), Diaz, Martinez, Fernandez |
| Fenix | 2 | Schetino, Amaral | ||
| 22-jun-2021 | Montevideo | River Plate | 0 | |
| Plaza Colonia | 1 | Rodriguez | ||
| 22-jun-2021 | Melo | Cerro Largo | 2 | Heredia, Brasil |
| Sud America | 1 | Camarda | ||
| 22-jun-2021 | Montevideo | Cerrito | 1 | Perez |
| Boston River | 0 | |||
| 23-jun-2021 | Montevideo | Villa Española | 0 | |
| Rentistas | 1 | Albin (A) | ||
| 23-jun-2021 | Montevideo | Torque | 0 | |
| Peñarol | 1 | Nahuelpan | ||
| 24-jun-2021 | Maldonado | Maldonado | 1 | Bogliacino |
| Progreso | 1 | Alles | ||
| 24-jun-2021 | Montevideo | Nacional | 3 | Bergessio (3, 1P) |
| Wanderers | 0 | |||
| 8º Fecha | ||||
| 26-jun-2021 | Montevideo | Fenix | 3 | Nequecaur, Herrera (A), Franco |
| River Plate | 4 | Arezo (2), Boggio, Bone | ||
| 26-jun-2021 | Montevideo | Peñarol | 1 | Alvarez |
| Villa Española | 1 | Silva | ||
| 27-jun-2021 | Las Piedras | Boston River | 1 | Larrosa |
| Liverpool | 1 | Loffrda | ||
| 27-jun-2021 | Montevideo | Rentistas | 1 | Villar |
| Nacional | 1 | Vega | ||
| 27-jun-2021 | Colonia | Plaza Colonia | 1 | Leonai |
| del Sacramento | Cerro Largo | 1 | D'Altoe | |
| 27-jun-2021 | Montevideo | Torque | 2 | Del Prete, Teuten |
| Maldonado | 3 | Toledo, Aguirregaray (2) | ||
| 29-jun-2021 | Montevideo | Sud America | 2 | Olivera, Camarda |
| Progreso | 4 | Alles (2), Morales, Roldan | ||
| 29-jun-2021 | Montevideo | Wanderers | 1 | Lopez |
| Cerrito | 0 | |||
| 9º Fecha | ||||
| 3-jul-2021 | Montevideo | Villa Española | 2 | Rios, P. Silva |
| Torque | 3 | F. Silva (A), Teuten, Pizzichillo | ||
| 3-jul-2021 | Montevideo | River Plate | 1 | Arezo |
| Boston River | 1 | Bentancourt | ||
| 3-jul-2021 | Melo | Cerro Largo | 1 | Onetto |
| Fenix | 2 | Franco, Alfaro | ||
| 4-jul-2021 | Maldonado | Maldonado | 1 | Fernandez |
| Sud America | 3 | Andrade (P), Mouche (P), Camarda | ||
| 4-jul-2021 | Montevideo | Nacional | 2 | Ocampo, Candido |
| Peñarol | 0 | |||
| 5-jul-2021 | Montevideo | Progreso | 1 | Marta |
| Plaza Colonia | 2 | Asconeguy (A), Mascia | ||
| 5-jul-2021 | Montevideo | Cerrito | 0 | |
| Rentistas | 1 | Barcia | ||
| 6-jul-2021 | Montevideo | Liverpool | 2 | Viega, Figueredo |
| Wanderers | 1 | Riolfo | ||
| 10º Fecha | ||||
| 10-jul-2021 | Montevideo | Villa Española | 2 | Tancredi (2) |
| Maldonado | 0 | |||
| 10-jul-2021 | Colonia | Plaza Colonia | 1 | Suhr |
| del Sacramento | Sud America | 0 | ||
| 10-jul-2021 | Montevideo | Wanderers | 1 | Quagliata |
| River Plate | 2 | Borbas, Arezo (P) | ||
| 11-jul-2021 | Las Piedras | Boston River | 1 | Rodriguez |
| Cerro Largo | 0 | |||
| 11-jul-2021 | Montevideo | Fenix | 2 | Barboza, Estoyanoff |
| Progreso | 1 | Alles | ||
| 11-jul-2021 | Montevideo | Torque | 3 | Rodriguez, Cejas, Pizzichillo |
| Nacional | 0 | |||
| 11-jul-2021 | Montevideo | Peñarol | 2 | Nahuelpan, Kagelmacher |
| Cerrito | 0 | |||
| 12-jul-2021 | Montevideo | Rentistas | 2 | Sosa, Rocha |
| Liverpool | 1 | Ramirez | ||
| 11º Fecha | ||||
| 16-jul-2021 | Montevideo | Progreso | 1 | Morales |
| Boston River | 0 | |||
| 17-jul-2021 | Montevideo | River Plate | 0 | |
| Rentistas | 0 | |||
| 17-jul-2021 | Maldonado | Maldonado | 0 | |
| Plaza Colonia | 1 | Camargo | ||
| 17-jul-2021 | Melo | Cerro Largo | 2 | Cayetano, Paiva |
| Wanderers | 0 | |||
| 24-jul-2021 | Montevideo | Sud America | 1 | Etchebarne |
| Fenix | 1 | Pereira | ||
| 24-jul-2021 | Montevideo | Torque | 0 | |
| Cerrito | 2 | Silvera (2P) | ||
| 25-jul-2021 | Montevideo | Liverpool | 3 | Martinez, Fernandez, Medina |
| Peñarol | 3 | Ceppelini (2P), Alvarez | ||
| 25-jul-2021 | Montevideo | Nacional | 3 | Bergessio, Ocampo, D'Alessandro |
| Villa Española | 0 | |||
| 12º Fecha | ||||
| 30-jul-2021 | Montevideo | Rentistas | 1 | Rodales |
| Cerro Largo | 3 | Otormin (2, 1P), Paiva | ||
| 31-jul-2021 | Las Piedras | Boston River | 2 | Labandeira, Barja |
| Sud America | 0 | |||
| 31-jul-2021 | Montevideo | Wanderers | 2 | Lopez, Rivero |
| Progreso | 0 | |||
| 1-ago-2021 | Montevideo | Torque | 0 | |
| Liverpool | 3 | Fernandez, Martirena, Chacon | ||
| 1-ago-2021 | Montevideo | Fenix | 0 | |
| Plaza Colonia | 1 | Diogo | ||
| 1-ago-2021 | Montevideo | Peñarol | 2 | Alvarez, Torres |
| River Plate | 0 | |||
| 1-ago-2021 | Montevideo | Nacional | 2 | Bergessio, Fernandez |
| Maldonado | 0 | |||
| 2-ago-2021 | Montevideo | Villa Española | 1 | Riquero |
| Cerrito | 1 | Silvera | ||
| 13º Fecha | ||||
| 6-ago-2021 | Montevideo | Progreso | 2 | Rodriguez, Morales |
| Rentistas | 2 | Bentaberry (A), Villar | ||
| 6-ago-2021 | Melo | Cerro Largo | 0 | |
| Peñarol | 1 | Ceppelini | ||
| 7-ago-2021 | Montevideo | River Plate | 3 | Borbas, Montiel, Leites |
| Torque | 3 | Chocobar, Guerrero, Peña | ||
| 8-ago-2021 | Montevideo | Liverpool | 2 | Fernandez (P), Chacon |
| Villa Española | 2 | Flores, Riquero | ||
| 8-ago-2021 | Montevideo | Cerrito | 2 | Silvera (2, 1P) |
| Nacional | 0 | |||
| 9-ago-2021 | Montevideo | Sud America | 1 | Andrade |
| Wanderers | 0 | |||
| 9-ago-2021 | Colonia | Plaza Colonia | 0 | |
| del Sacramento | Boston River | 0 | ||
| 10-ago-2021 | Maldonado | Maldonado | 0 | |
| Fenix | 0 | |||
| 14º Fecha | ||||
| 14-ago-2021 | Montevideo | Rentistas | 1 | Acosta |
| Sud America | 2 | Andrade (P), Cayetano | ||
| 14-ago-2021 | Montevideo | Peñarol | 1 | Alvarez |
| Progreso | 0 | |||
| 15-ago-2021 | Montevideo | Villa Española | 1 | Silva |
| River Plate | 1 | Arezo | ||
| 15-ago-2021 | Montevideo | Torque | 3 | Guerrero (2), Alvarez |
| Cerro Largo | 0 | |||
| 15-ago-2021 | Montevideo | Nacional | 1 | Corujo |
| Liverpool | 0 | |||
| 15-ago-2021 | Montevideo | Wanderers | 0 | |
| Plaza Colonia | 2 | Zeballos, Dibble | ||
| 16-ago-2021 | Las Piedras | Boston River | 0 | |
| Fenix | 2 | Martirena, Alfaro | ||
| 16-ago-2021 | Montevideo | Cerrito | 0 | |
| Maldonado | 0 | |||
| 15º Fecha | ||||
| 20-ago-2021 | Montevideo | Progreso | 1 | Alles |
| Torque | 4 | Cejas (2), Allende (P), Perez | ||
| 20-ago-2021 | Montevideo | Fenix | 2 | Alvez, Rodriguez |
| Wanderers | 1 | Rivero | ||
| 21-ago-2021 | Montevideo | Liverpool | 3 | Martinez (2), Figueredo |
| Cerrito | 0 | |||
| 21-ago-2021 | Maldonado | Maldonado | 0 | |
| Boston River | 2 | Labandeira, Freitas | ||
| 21-ago-2021 | Montevideo | River Plate | 2 | Arezo, Boggio |
| Nacional | 0 | |||
| 22-ago-2021 | Colonia | Plaza Colonia | 2 | Diogo (2, 1P) |
| del Sacramento | Rentistas | 0 | ||
| 22-ago-2021 | Montevideo | Sud America | 1 | Andrade (P) |
| Peñarol | 1 | Ceppelini (P) | ||
| 22-ago-2021 | Melo | Cerro Largo | 3 | Paiva, Onetto, Otormin |
| Villa Española | 1 | Albin | ||
| Campeonato de Clausura | ||||
| 1º Fecha | ||||
| 11-sep-2021 | Montevideo | Sud America | 1 | Andrade (P) |
| Torque | 2 | Guerrero, Teuten | ||
| 11-sep-2021 | Montevideo | River Plate | 1 | Arezo |
| Cerrito | 0 | |||
| 11-sep-2021 | Tacuarembo | Cerro Largo | 1 | Otormin |
| Nacional | 1 | Risso | ||
| 12-sep-2021 | Montevideo | Fenix | 3 | Franco (3, 1P) |
| Rentistas | 1 | Urretaviscaya | ||
| 12-sep-2021 | Las Piedras | Boston River | 1 | Izquierdo (A) |
| Wanderers | 3 | Mendez, Rivero, Hernandez | ||
| 12-sep-2021 | Colonia | Plaza Colonia | 1 | Lopez |
| del Sacramento | Peñarol | 2 | Alvarez (2) | |
| 13-sep-2021 | Montevideo | Liverpool | 1 | Garcia |
| Maldonado | 0 | |||
| 13-sep-2021 | Montevideo | Progreso | 1 | Mieres |
| Villa Española | 1 | Silva | ||
| 2º Fecha | ||||
| 17-sep-2021 | Montevideo | Rentistas | 1 | Gonzalez (A) |
| Boston River | 2 | Labandeira (2) | ||
| 17-sep-2021 | Montevideo | Peñarol | 0 | |
| Fenix | 0 | |||
| 18-sep-2021 | Montevideo | Cerrito | 1 | Rodriguez |
| Cerro Largo | 1 | Di Yorio | ||
| 18-sep-2021 | Montevideo | Villa Española | 1 | Silva |
| Sud America | 2 | Mouche, Ramirez | ||
| 19-sep-2021 | Montevideo | Liverpool | 3 | Martinez (P), Fernandez, Martirena |
| River Plate | 1 | Borbas | ||
| 19-sep-2021 | Montevideo | Nacional | 0 | |
| Progreso | 1 | Colman | ||
| 19-sep-2021 | Montevideo | Torque | 2 | Rodriguez, Guerrero |
| Plaza Colonia | 2 | Calleros, Suhr | ||
| 20-sep-2021 | Maldonado | Maldonado | 1 | Casas |
| Wanderers | 3 | Mendez (2P), Abero | ||
| 3º Fecha | ||||
| 24-sep-2021 | Colonia | Plaza Colonia | 4 | Dibble (P), Lopez, Calleros, Camargo |
| del Sacramento | Villa Española | 0 | ||
| 25-sep-2021 | Montevideo | River Plate | 1 | Arezo |
| Maldonado | 2 | Viatri (P), Darias | ||
| 25-sep-2021 | Tacuarembo | Cerro Largo | 3 | Otormin, Di Yorio, Cayetano |
| Liverpool | 0 | |||
| 25-sep-2021 | Montevideo | Sud America | 0 | |
| Nacional | 2 | Zunino, Bergessio (P) | ||
| 26-sep-2021 | Montevideo | Progreso | 0 | |
| Cerrito | 1 | Silvera | ||
| 26-sep-2021 | Montevideo | Fenix | 1 | Rodriguez |
| Torque | 1 | Cejas | ||
| 26-sep-2021 | Las Piedras | Boston River | 2 | Davila, Labandeira |
| Peñarol | 5 | Nahuelpan (2, 1P), Canobbio, Torres, Lozano (A) | ||
| 26-sep-2021 | Montevideo | Wanderers | 2 | Pais, Rivero |
| Rentistas | 1 | Veglio (A) | ||
| 4º Fecha | ||||
| 1-oct-2021 | Maldonado | Maldonado | 2 | Viatri (2) |
| Rentistas | 1 | Urretaviscaya | ||
| 1-oct-2021 | Montevideo | Cerrito | 2 | Silvera, Scarone |
| Sud America | 0 | |||
| 2-oct-2021 | Montevideo | Villa Española | 1 | Silva |
| Fenix | 2 | Pereira, Franco | ||
| 2-oct-2021 | Montevideo | River Plate | 0 | |
| Cerro Largo | 4 | Brasil, Di Yorio, Cayetano, Onetto | ||
| 3-oct-2021 | Montevideo | Liverpool | 0 | |
| Progreso | 1 | Silva | ||
| 3-oct-2021 | Montevideo | Nacional | 2 | Candido, Ramirez |
| Plaza Colonia | 1 | Lopez | ||
| 3-oct-2021 | Montevideo | Torque | 4 | L. Rodriguez, Guerrero (2), Teuten |
| Boston River | 3 | Gonzalez, Fernandez, F. Rodriguez | ||
| 3-oct-2021 | Montevideo | Peñarol | 3 | Rivero (A), Laquintana (2) |
| Wanderers | 0 | |||
| 5º Fecha | ||||
| 8-oct-2021 | Tacuarembo | Cerro Largo | 1 | Di Yorio |
| Maldonado | 1 | Muniz | ||
| 9-oct-2021 | Montevideo | Progreso | 1 | Olaizola |
| River Plate | 0 | |||
| 9-oct-2021 | Maldonado | Rentistas | 0 | |
| Peñarol | 1 | Pereira | ||
| 9-oct-2021 | Montevideo | Wanderers | 0 | |
| Torque | 1 | Rodriguez | ||
| 10-oct-2021 | Las Piedras | Boston River | 1 | Rodriguez |
| Villa Española | 0 | |||
| 10-oct-2021 | Montevideo | Sud America | 0 | |
| Liverpool | 1 | Garcia | ||
| 10-oct-2021 | Montevideo | Fenix | 1 | Marichal (A) |
| Nacional | 2 | Cantera, Mendez | ||
| 11-oct-2021 | Colonia | Plaza Colonia | 3 | Zeballos (2), Lopez |
| del Sacramento | Cerrito | 3 | Olivera (A), Ortiz, Silvera | |
| 6º Fecha | ||||
| 16-oct-2021 | Montevideo | River Plate | 5 | Castro (2), Garcia, leites (P), Affonso |
| Sud America | 1 | Mouche | ||
| 16-oct-2021 | Montevideo | Torque | 1 | Cabrera |
| Rentistas | 2 | Rodriguez (2) | ||
| 16-oct-2021 | Montevideo | Liverpool | 0 | |
| Plaza Colonia | 1 | Rodriguez | ||
| 16-oct-2021 | Montevideo | Nacional | 3 | Trezza, Ramirez, Fernandez |
| Boston River | 2 | Rodriguez, Alvarez | ||
| 17-oct-2021 | Montevideo | Villa Española | 2 | Machado, Godoy |
| Wanderers | 2 | Rivero, Veglio | ||
| 17-oct-2021 | Melo | Cerro Largo | 1 | Estol |
| Progreso | 0 | |||
| 17-oct-2021 | Maldonado | Maldonado | 1 | Ramos |
| Peñarol | 0 | |||
| 17-oct-2021 | Montevideo | Cerrito | 2 | Rodriguez, Aviles |
| Fenix | 4 | Amaral (2), Franco (P), Rodriguez | ||
| 7º Fecha | ||||
| 20-oct-2021 | Montevideo | Rentistas | 3 | Rodriguez (2, 1P), Villar |
| Villa Española | 1 | Olivera | ||
| 20-oct-2021 | Montevideo | Fenix | 1 | G. Viera |
| Liverpool | 1 | S. Viera | ||
| 20-oct-2021 | Colonia | Plaza Colonia | 0 | |
| del Sacramento | River Plate | 0 | ||
| 20-oct-2021 | Montevideo | Peñarol | 3 | Torres (2), Alvarez |
| Torque | 1 | Brun | ||
| 21-oct-2021 | Montevideo | Sud America | 0 | |
| Cerro Largo | 0 | |||
| 21-oct-2021 | Las Piedras | Boston River | 3 | Labandeira (3) |
| Cerrito | 2 | Silvera (2) | ||
| 21-oct-2021 | Montevideo | Progreso | 2 | Lima (A), Colman |
| Maldonado | 0 | |||
| 21-oct-2021 | Montevideo | Wanderers | 1 | Aguirre |
| Nacional | 0 | |||
| 8º Fecha | ||||
| 23-oct-2021 | Montevideo | Villa Española | 1 | Olivera |
| Peñarol | 3 | Ceppelini (P), Alvarez, Canobbio | ||
| 24-oct-2021 | Maldonado | Maldonado | 2 | Lima, Cotugno |
| Torque | 1 | Alvarez | ||
| 24-oct-2021 | Montevideo | Liverpool | 2 | Martirena, Figueredo |
| Boston River | 2 | F. Rodriguez, A. Rodriguez | ||
| 24-oct-2021 | Montevideo | Cerrito | 2 | Silvera (2) |
| Wanderers | 2 | Pais, Mendez (P) | ||
| 24-oct-2021 | Montevideo | Nacional | 2 | Ramirez, Fernandez (P) |
| Rentistas | 2 | Urretaviscaya, Rodriguez | ||
| 25-oct-2021 | Montevideo | Progreso | 0 | |
| Sud America | 0 | |||
| 25-oct-2021 | Melo | Cerro Largo | 1 | Bueno (P) |
| Plaza Colonia | 0 | |||
| 25-oct-2021 | Montevideo | River Plate | 0 | |
| Fenix | 0 | |||
| 9º Fecha | ||||
| 29-oct-2021 | Montevideo | Rentistas | 1 | S. Rodriguez |
| Cerrito | 2 | Y. Rodriguez, F. Rodriguez | ||
| 29-oct-2021 | Montevideo | Wanderers | 1 | Aguirre |
| Liverpool | 0 | |||
| 30-oct-2021 | Las Piedras | Boston River | 1 | Rodriguez |
| River Plate | 2 | Galletto, Arezo (P) | ||
| 30-oct-2021 | Montevideo | Sud America | 1 | Caballero |
| Maldonado | 1 | Casas | ||
| 30-oct-2021 | Colonia | Plaza Colonia | 2 | Zeballos, Rodriguez |
| del Sacramento | Progreso | 1 | Guirin (A) | |
| 30-oct-2021 | Montevideo | Torque | 5 | Allende (P), Catarozzi, Rodriguez (2), Pereira |
| Villa Española | 0 | |||
| 31-oct-2021 | Montevideo | Fenix | 1 | Ramos |
| Cerro Largo | 4 | Onetto, Otormin (3, 1P) | ||
| 31-oct-2021 | Montevideo | Peñarol | 0 | |
| Nacional | 0 | |||
| 10º Fecha | ||||
| 2-nov-2021 | Maldonado | Maldonado | 0 | |
| Villa Española | 1 | Ramirez | ||
| 3-nov-2021 | Montevideo | River Plate | 0 | |
| Wanderers | 1 | Veglio | ||
| 3-nov-2021 | Montevideo | Liverpool | 0 | |
| Rentistas | 1 | Rodriguez | ||
| 3-nov-2021 | Montevideo | Nacional | 2 | Zunino, Almeida |
| Torque | 0 | |||
| 4-nov-2021 | Montevideo | Progreso | 1 | Colman |
| Fenix | 0 | |||
| 4-nov-2021 | Melo | Cerro Largo | 1 | Di Yorio |
| Boston River | 1 | Brasil (A) | ||
| 4-nov-2021 | Montevideo | Sud America | 1 | Caballero |
| Plaza Colonia | 1 | Dibble | ||
| 4-nov-2021 | Montevideo | Cerrito | 1 | Silvera |
| Peñarol | 3 | Bentancourt (3) | ||
| 11º Fecha | ||||
| 6-nov-2021 | Montevideo | Rentistas | 1 | Viudez |
| River Plate | 0 | |||
| 6-nov-2021 | Montevideo | Villa Española | 1 | Lopez |
| Nacional | 2 | Bergessio, Fernandez (P) | ||
| 7-nov-2021 | Montevideo | Cerrito | 0 | |
| Torque | 2 | Pereira, Rodriguez | ||
| 7-nov-2021 | Montevideo | Peñarol | 1 | Ceppelini (P) |
| Liverpool | 0 | |||
| 8-nov-2021 | Montevideo | Fenix | 1 | Pereira |
| Sud America | 2 | Morales, Andrade | ||
| 8-nov-2021 | Las Piedras | Boston River | 0 | |
| Progreso | 0 | |||
| 8-nov-2021 | Montevideo | Wanderers | 1 | Hernandez |
| Cerro Largo | 2 | Max, Di Yorio | ||
| 8-nov-2021 | Colonia | Plaza Colonia | 1 | Dibble |
| del Sacramento | Maldonado | 0 | ||
| 12º Fecha | ||||
| 13-nov-2021 | Montevideo | Liverpool | 1 | Martinez |
| Torque | 3 | Arismendi, Guerrero, Alvarez | ||
| 13-nov-2021 | Maldonado | Maldonado | 1 | Varela |
| Nacional | 0 | |||
| 13-nov-2021 | Montevideo | Cerrito | 1 | Rodriguez |
| Villa Española | 0 | |||
| 14-nov-2021 | Montevideo | Sud America | 1 | Ramirez |
| Boston River | 2 | Alberti, Alvarez | ||
| 14-nov-2021 | Montevideo | River Plate | 1 | Galletto |
| Peñarol | 1 | Ceppelini (P) | ||
| 14-nov-2021 | Colonia | Plaza Colonia | 1 | Amaral (A) |
| del Sacramento | Fenix | 1 | Vega | |
| 15-nov-2021 | Melo | Cerro Largo | 1 | Di Yorio |
| Rentistas | 1 | Rodriguez (P) | ||
| 15-nov-2021 | Montevideo | Progreso | 3 | Rodriguez, Bentaberry, Colman |
| Wanderers | 1 | Riolfo | ||
| 13º Fecha | ||||
| 18-nov-2021 | Montevideo | Nacional | 1 | Fernandez |
| Cerrito | 0 | |||
| 19-nov-2021 | Montevideo | Villa Española | 0 | |
| Liverpool | 3 | Martinez (2), Fernandez | ||
| 19-nov-2021 | Montevideo | Fenix | 2 | Amaral, Viera |
| Maldonado | 1 | Tealde | ||
| 19-nov-2021 | Montevideo | Wanderers | 4 | Pais, Rivero (3, 1P) |
| Sud America | 1 | Ramirez (P) | ||
| 21-nov-2021 | Montevideo | Rentistas | 0 | |
| Progreso | 1 | Colman (P) | ||
| 22-nov-2021 | Las Piedras | Boston River | 2 | Rodriguez, Larrosa |
| Plaza Colonia | 0 | |||
| 22-nov-2021 | Montevideo | Torque | 1 | Teuten |
| River Plate | 1 | Arezo | ||
| 22-nov-2021 | Montevideo | Peñarol | 2 | Alvarez, Rodriguez |
| Cerro Largo | 2 | Di Yorio, Otormin | ||
| 14º Fecha | ||||
| 25-nov-2021 | Maldonado | Maldonado | 0 | |
| Cerrito | 1 | Da Silva | ||
| 25-nov-2021 | Montevideo | Progreso | 0 | |
| Peñarol | 0 | |||
| 26-nov-2021 | Montevideo | Sud America | 3 | Ramirez, Caballero, Santeyano |
| Rentistas | 1 | Lopez (A) | ||
| 26-nov-2021 | Montevideo | Liverpool | 2 | Martinez, Fernandez |
| Nacional | 2 | Bergessio, Trezza | ||
| 26-nov-2021 | Colonia | Plaza Colonia | 0 | |
| del Sacramento | Wanderers | 1 | Quagliata | |
| 29-nov-2021 | Melo | Cerro Largo | 1 | Max |
| Torque | 1 | Guerrero | ||
| 30-nov-2021 | Montevideo | River Plate | 4 | Leites, Arezo (P), Boggio (2) |
| Villa Española | 2 | Lopez (P), Ramirez | ||
| 30-nov-2021 | Montevideo | Fenix | 0 | |
| Boston River | 0 | |||
| 15º Fecha | ||||
| 4-dic-2021 | Las Piedras | Boston River | 2 | Rodriguez (P), Gonzalez |
| Maldonado | 1 | Viatri | ||
| 4-dic-2021 | Montevideo | Wanderers | 1 | Blanco |
| Fenix | 1 | Pereira (P) | ||
| 4-dic-2021 | Montevideo | Rentistas | 2 | Rodriguez (2, 1P) |
| Plaza Colonia | 3 | Mascia, Suhr, Ruiz Diaz | ||
| 4-dic-2021 | Montevideo | Peñarol | 3 | Canobbio, Trindade (2) |
| Sud America | 1 | Andrade | ||
| 4-dic-2021 | Montevideo | Torque | 1 | Guerrero |
| Progreso | 0 | |||
| 4-dic-2021 | Montevideo | Nacional | 4 | Almeida, Brunelli (2A), Fernandez |
| River Plate | 2 | Borbas, Montiel | ||
| 5-dic-2021 | Montevideo | Villa Española | 1 | Tizon |
| Cerro Largo | 1 | Di Yorio | ||
| 5-dic-2021 | Montevideo | Cerrito | 2 | Silvera (2P) |
| Liverpool | 1 | Figueredo | ||
| Semifinal Campeonato | ||||
| 7-dic-2021 | Montevideo | Plaza Colonia | 1(7) | Lopez (P) |
| Peñarol | 1(8) | Torres | ||